When a villain threatens to evict all the pets in the city, a group of secret-agent talking animals must join forces to stop him and save their owners.

In a world where cats and dogs have been battling for centuries, an eccentric professor creates a formula that turns animals into super soldiers. A young beagle puppy must team up with a brave, self-assured cat to stop an evil cat from creating a serum that will make all humans allergic to dogs.

When a rogue cat named Kitty Galore plans to take revenge on both cats and dogs, it's up to a special agent dog and a rookie cat to stop her. They must put aside their differences and work together to save their species.