Men of Boys Town is a heartwarming drama set in a Catholic orphanage. The film follows the struggles and triumphs of the boys who live in the orphanage, as they navigate challenges such as financial crises, juvenile delinquency, and the need for social reform. Throughout the film, themes of self-sacrifice, determination, and the power of community are explored.

Boys Town is a boys' boarding school in Nebraska run by Father Edward J. Flanagan. When a young troublemaker named Whitey Marsh comes to Boys Town, he starts a series of pranks and conflicts with another boy, Pee Wee. But as they both face challenges and learn valuable life lessons, they become friends and work together to save the reputation of Boys Town.