In Bedtime for Bonzo, a college professor takes on the challenge of raising a mischievous chimpanzee named Bonzo as part of a social experiment. Chaos and hilarity ensue as Bonzo wreaks havoc on the professor's life, causing scandal and creating a lot of gossip on campus. The professor must navigate his personal and professional life while dealing with Bonzo's antics, leading to unexpected and comedic situations.

When Bonzo turns out to be the answer to the football teams troubles, the only solution is to enroll him into a college.