Blade forms an alliance with the vampire council and the Bloodpack to fight against the Reapers, a group of vampires who feed on both humans and vampires. As the Reapers become an increasing threat, Blade must navigate treachery and betrayal to save both humans and vampires. The true identity of the leader of the Reapers is revealed, and Blade must confront him in a final showdown.

Blade is a half-vampire, half-mortal man who takes on the role of protecting the mortal race from evil vampires. With enhanced strength and vampire abilities, Blade fights to maintain a peaceful coexistence between vampires and humans. Alongside his mentor Whistler, Blade encounters Deacon Frost, a vampire who seeks to rule over humans. As Blade battles Frost and his followers, he discovers his own unique abilities and the true significance of the ancient vampire prophecies. In a climactic showdown, Blade saves humanity and continues his mission to hunt down vampires.

Blade, now a wanted man by the FBI, must join forces with the Nightstalkers to face his most challenging enemy yet: Dracula. After Whistler sacrifices himself, Blade is captured by the FBI but is saved by the Nightstalkers. Together, they discover that Dracula has been reawakened by the vampires to help with their final solution. Blade and the Nightstalkers must stop Dracula and his vampire army with the help of a new weapon, the DayStar virus.