After a family tragedy, three generations of the Deetz family return home to Winter River. Still haunted by Betelgeuse, Lydia's life is turned upside down when her teenage daughter, Astrid, accidentally opens the portal to the Afterlife.
In a sleepy town in New England, deceased couple Barbara and Adam Maitland return to their home and try to scare away the Deetzes, a New York family who has just moved in. When their attempts fail, they seek the help of a malicious spirit named Beetlejuice. However, they soon regret their decision as Beetlejuice turns out to be crazy and uncontrollable. The Maitlands must find a way to scare the Deetzes themselves and protect their home, while also forming a bond with the teenage daughter Lydia.