During an archaeological expedition on Bouvetøya Island in Antarctica, a team of scientists find themselves caught up in a battle between Aliens and Predators. As they explore an ancient pyramid, they inadvertently awaken an Alien queen and become trapped. With the help of a lone Predator, the surviving humans must fight to escape as the Aliens multiply. They discover that the Predators have been visiting Earth for centuries, using humans as hosts for the Aliens in a hunt. The survivors must ensure the Predators succeed in their hunt to prevent the Aliens from spreading further.

In a small Colorado town, two Predators and a crew of humans must band together to survive when an Alien-Predator hybrid and a horde of Aliens are unleashed. As the townspeople are attacked, they realize that the military has a secret plan to use them as bait. With the help of a Predator soldier, the survivors fight back against the extraterrestrial invaders and escape the town before it is destroyed. Meanwhile, a government agent learns about the technology possessed by the Predators and seeks to prevent it from being used on Earth.