A group of scientists must stop a dangerous experiment with genetic regeneration involving anacondas. As they navigate through a forest, they encounter betrayal, murder, and a deadly predator.

A team of scientists embarks on a dangerous expedition to Borneo in search of the rare Blood Orchid, which is believed to hold the key to immortality. As they venture deeper into the jungle, they face terrifying encounters with giant anacondas, aggressive crocodiles, deadly spiders, and other monstrous creatures. With time running out and their lives on the line, they must find a way to survive and escape before they become the prey of the ruthless predators lurking in the shadows.

A film crew shooting a documentary in the Amazon River encounters a snake hunter who takes them hostage to help him capture a giant anaconda. As they struggle to survive, the crew members are killed one by one. In the end, they manage to defeat the hunter and the snake, and find the native tribe they were originally searching for.

In Anaconda 3: Offspring, a group of mercenaries and scientists are on an expedition in the jungle when they encounter a genetically-enhanced anaconda. As they fight for their survival, they must navigate treacherous terrain and deadly encounters with the monstrous snake.