In All Dogs Go to Heaven 2, Charlie and Itchy return to Earth to retrieve Gabriel's horn and prevent a demonic cat from taking over Heaven. Along the way, they befriend a young boy named David and encounter various challenges and obstacles. Will they be able to save Heaven and find their own redemption?

When a loan shark threatens to ruin Christmas for all the dogs in San Francisco, they must come together and learn the true meaning of the holiday season. With the help of an angel, they embark on a journey of redemption, compassion, and the power of friendship.

After being murdered by his former partner, a German Shepherd named Charlie is given a second chance at life when he returns from heaven. He seeks revenge on his killer while befriending a young orphan girl named Anne-Marie.